Guggul (Commiphora mukul) : Guggulu possesses potent Vatashamaka property thus relieves pain and inflammation of joints.1 Guggulosterol, the active sterol constituent of Commiphora mukul down-regulates the expression of inflammatory products such as COX- 2(Cyclo-oxygenase 2) and MMP-9 (Matrix metallopeptidase-9) which are the major players in the development of Arthritis. It also shows chondro protective property which significantly decreases the cartilage degradation in Arthritis
Shallaki (Boswellia serrata) : Shallaki is a potent anti-inflammatory agent and has been used in the management of Vata Roga since thousands of years. Boswellic acids, the major active constituent of Boswellia serrata inhibits synthesis of inflammatory mediators such as 5-lipooxygenase and leukotriene B4 which prevents the migration of inflammation-producing cells to the inflamed joint,Calcium dislocation and cell adhesion. Its oleo gum resin posses immunodulatory and anti-inflammatory activity, quercetine (other chemical compound) decreases the free radical induced damage and acts as an anti-oxidant.
Nirgundi (Vitex negundo) : Nirgundi is used to treat several types of Vata rogas and possesses anti-inflammatory and analgesic activity, these activities are mediated via PG (Prostaglandin) synthesis inhibition, anti-histamine, membrane stabilizing and anti-oxidant properties. Vitex negundo possesses both central and peripheral analgesic activity.
Chopchini (Smilax china) : Chopchini has been used to treat Vatavyadhi. It inhibits IL-1 (Interlukin-1)beta, TNF (Tumor necrosis factor)-alpha, NO (Nitric oxide)and COX-II(Cyclo-oxygenase II) enzymes thus useful in Arthritis. It acts as a tonic and maintains general health by regulating both cell mediated and humoral immunity.
Methi (Trigonella foenum graecum) : Methi mucilage possesses significant anti-inflammatory [by inhibiting the inflammatory enzymes like COX-II (Cyclooxygenase- II), LO (Lipo oxygenase), Myeloperoxidase] and antioxidant (decreases level of nitrite and C-reactive protein) effects in arthritic patients.
Lasun (Allium sativum) : Lasun has been used to treat various types of diseases including inflammation of joints. Thiacremonone a novel active compound possesses anti-inflammatory and anti-arthritic properties.
Pippali (Piper longum) : Pippali acts as a bio-availability enhancer in this formulation thus increasing the bioavailability of active herbal compounds at the site of action (joints and cartilages).